Organs from drug overdoses could alleviate transplant shortage

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In South Africa, there are currently approximately 4 300 patients desperately waiting for a life-saving organ transplant.

Yet, the latest statistics from the Organ Donation Foundation states that only 512 transplants were performed in 2016, 25 of them being heart transplants. The question has been asked – how can we ensure more organ transplants?

New studies show that fatal drug overdoses are increasing organ donations, and according to researchers, people who receive those transplants generally fare as well as patients given organs from more traditional donors.

What the study entailed

The findings could encourage greater use of organs from overdose victims. Researchers from Johns Hopkins University found those transplants have jumped nearly 24-fold since 2000. That was before most transplant centres considered accepting such organs.

In 2016 there were 3 533 transplants using overdose-related donated organs in the US, up from just 149 such transplants in 2000, the study found.

Deaths from overdoses are on the rise, yet most occur outside hospitals, blocking organ donation. Still, those deaths now account for about 13% of the nation’s deceased organ donors, up from 1% in 2000, the researchers calculated.

“This is not an ideal or sustainable solution to the organ shortage,” lead researcher Dr Christine Durand wrote in the journal Annals of Internal Medicine.

But with nearly 115 000 people on the national waiting list for a transplant, the Hopkins team concluded that use of organs from overdoses “should be optimised” because many transplant candidates could die waiting for another choice.

Research based on American figures

For the current study, the researchers used a US registry to compare the outcomes of nearly 338 000 patients who received a transplant between 2000 and 2016, from either a donor who died of disease, trauma or an overdose.

In general, transplant recipients’ survival was similar with an organ from an overdose victim. In fact, compared to donors who died of disease, they sometimes fared a little better because overdose donors tend to be younger and less likely to have had high blood pressure, diabetes or other ailments that can affect an organ’s function, the researchers reported.

The study found that overdose-related organs are more likely than other donated organs to be classified as at “increased risk” of infectious diseases such as HIV or hepatitis C. But the Hopkins team said with improved testing of all donated organs to uncover infections – and new, effective medications for hepatitis C – the overall risk for transplant candidates is low, and should be carefully weighed in determining the best option for individual patients.

“It’s reassuring that these organs do work well and provide a lot of benefits,” said Dr David Klassen, chief medical officer of the United Network for Organ Sharing, which oversees the US transplant system. He wasn’t involved in the research.

If this is the case, it could change the scope for organ donation worldwide.



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